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N Engl J Med 336:633640 Foncea R, Andersson M, Ketterman A et al (1997) Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes

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As a disulfide bond can be cleaved and hence reduced by the excess concentration of a thiol (sulfhydryl) like -mercaptoethanol (which gets oxidized in the process), the free thiol on glutathione can act as a reducing agent in the cell

While the complex relationship between CFTR dysfunction and oxidative stress, as well as the clinical outcomes of antioxidant therapies, have been discussed at length in numerous excellent reviews (Galli et al., 2012