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This cycle continues with the newly formed L-citrulline converting back to L-arginine, creating a sustainable supply of NO precursors

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Ros mediated ER stress induces bax-bak dependent and independent apoptosis in response to thioridazine

As discussed, a key limitation to the use of the CPZ model in vivo is the rapid remyelination seen on cessation of treatment (Blakemore, 1972)