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It occurs during numerous pathological processes and causes anaemia, one of the most frequent side effects of cancer chemotherapy

Preserving the connectivity of the mitochondrial network is vital as it represents a significant contributing factor to proper cellular function in individuals with T21

Cadmium and arsenic can sustain estrogenic signaling and activate MAPK/ERK and PI3K/Akt pathways even under tamoxifen treatment, while arsenic-mediated BRCA1 methylation further reduces drug responsiveness