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These TRM cells exhibit high levels of CD122, the IL-15 receptor subunit.3437 This antibody has demonstrated disease reversal in mice, making it a promising therapeutic target.38 Recently, it has been shown that TRM survival depends on the uptake and metabolism of exogenous fatty acids, suggesting that a possible treatment could be the regulation of lipid metabolism, focused on the elimination of TRMs in peripheral tissues.39 Intrinsic melanocyte abnormalities and epidermal and dermal alterations in vitiligo skin Several in vitro and in vivo studies have demonstrated the presence of intrinsic abnormalities in vitiligo melanocytes characterized by increased susceptibility to pro-oxidant agents

This therapeutic strategy, by alleviating oxidative stress and blocking key stages in stone formation, could offer more effective and personalized treatment options for patients

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This primarily stems from internal differences, like the amount of intrinsic factor released in the stomach or genetic defects (much like an MTHFR mutation)

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