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In this work, we explored the biological effect of nano-SARs, by developing a microenvironment-responsive in vivo self-assembled peptide-ferriporphyrin conjugates ( Gi-F-CAA ) for improving tumor penetration, accumulation and binding affinity with GPX4, ultimately synergistically enhancing ferroptosis-based anticancer activity

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Therefore, IGF-1 may indirectly modulate carbohydrate metabolism through GH suppression and enhancement of insulin action

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Undoubtedly, autophagy is indispensable in the selective degradation of damaged organelles and misfolded proteins, thereby repressing neuronal injury, improving cognitive function and enhancing neuronal survival (Cerri and Blandini 2019)