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For instance, interferon- (IFN-) released by cytotoxic T cells (CTLs) activates the downstream JAK-STAT1 signaling pathway, downregulating the expression of the cystine/glutamate antiporter system (xc system), thereby reducing intracellular GSH synthesis, increasing free iron levels, and ultimately inducing ferroptosis in GBM cells [91]

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Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)