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While the possibility that long-term meat-eating itself increases TMAO levels remains a legitimate hypothesis to be investigated, equal investigation should be given to alternative hypotheses focusing on other dietary and lifestyle factors that differ between vegetarians and omnivores

2D) in the heparinized plasma compared to the EDTA-treated plasma, both of which were deproteinized and stored at 80 o C prior to quantification

All patients provided written informed consent for sample collection and data analysis

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