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Conclusion This review summarized the current literature highlighting the negative effects of MDM2p53 axis dysfunction in the context of hepatoma cells transformation (Table 2)

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Cells were routinely passaged in 0.2% gelatine-coated (Sigma, Steinheim, Germany) polysterene culture flasks (TPP, Trasadingen, Switzerland) in endothelial growth medium (Lonza, Anaheim, CA, USA) in a humidified atmosphere containing 5% CO 2