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10.1097/00149831-200512000-00013 116 LewisP

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Generalized hypo- or areflexia Strongly Supportive of Diagnosis Progression of symptoms from days to 4 weeks Relative symmetry of symptoms Mild sensory symptoms Cranial nerves involvements Autonomic dysfunction High CSF protein Typical electrodiagnostic features Features that raise doubt about the diagnosis Severe pulmonary dysfunction with limited limb weakness Severe sensory signs with limited weakness Bladder or bowel dysfunction at onset Fever at onset Sharp sensory level Marked persistent asymmetry of weakness Persistent bladder dysfunction Increased number of mononuclear cells in CSF Treatment Treatment of GBS has two components: Supportive care and Specific therapy

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By identifying early synaptic changes, scientists can help improve diagnosis, monitor disease progression, and develop more effective treatments