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To mitigate these effects, plants activate sophisticated antioxidant defense networks involving enzymes such as superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), and glutathione peroxidase (GPX), as well as non-enzymatic antioxidants, including phenolics, flavonoids, anthocyanins, and lignin (Fujita and Hasanuzzaman 2022)

Lumbrokiase, the active metabolite, exhibits significantly greater activity compared to crude earthworm extract ( Dilong )

For a research laboratory, these studies offer benchmarks but do not constitute a rigorous level A evidence framework

PPAR activation in adipocytes is sufficient for systemic insulin sensitization

the latter refers to the process of converting sepiapterin as a substrate to BH2 and further reduction to BH4 ( de novo and salvage pathways to the cellular availability of BH4 varies depending on the cell type