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Although DEX increases NPT1 and NPT4, it significantly reduces OAT3 expression in mouse kidney, which also shows the complex roles of DEX on urate absorption (Li et al., 2019)

The underlying mechanism is that angiotensin II binds to angiotensin II type 1 (AT1) receptor and then activates JAK/STAT signaling to induce IL-6 production

This increases the risk that: Products may be contaminated or mislabeled Adverse events may not be monitored or reported Patients may be misled about efficacy 4

Widely used in clinical settings with trusted performance

The authors propound that deficient islet GABA signaling/content may contribute to the hyper-glucagonemia of T2D which again reinforces a role for GABA-based therapeutics