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Meanwhile, pro-caspase-1 will be recruited and activated by the ASC domain of the inflammasome, cleaves itself into active caspase-1, which is involved in the maturation of interleukin precursor molecules, resulting in a widespread inflammatory response [17, 20]

Increased FDX1 activity and mitochondria-dependent energy metabolism are strong inducers of the cytotoxic effects of elesclomol-mediated cuproptosis (Tsvetkov et al., 2019) and inhibit Fe-S cluster biosynthesis (Tsvetkov et al., 2019)

Meanwhile, research has shown that A may also induce the generation of reactive oxygen species (ROS) through various pathways, causing lipid peroxidation and neuronal oxidative stress, which causes further neuroinflammatory injury [17,18,19]

Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies

MIA PaCa-2, Human pancreatic adenocarcinoma cell line