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Importantly, we also found that Mn accumulates in slc39a11 mutant zebrafish, as well as in the serum of both global Slc39a11 knockout and hepatocyte-specific Slc39a11 knockout mice, suggesting that this metal transporter regulates systemic Mn levels 54

Crit Care Med 2011, 39: 1263-1268

Xing X, Liang Y, Li Y, Zhao Y, Zhang Y, Li Z, et al

doi: 10.1111/ijfs.16096

Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology