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Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]

In contrast, alizarin-type anthraquinones, prevalent in the Rubiaceae , often display substitution patterns that facilitate their role as stable pigments and rhizosphere-active compounds, affecting both pollinator attraction and soil community composition (Han et al., 2001

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