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Disturbance of cellular redox homeostasis may activate transcription factors and gene expression of those involved in the protection of plants against damage during chilling and cold acclimation (Kocsy et al., 2001)

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Wang et al (136) reported that the deposition of copper in WD may perturb the secretion of reproductive hormones by inducing apoptosis in hypothalamic-pituitary cells and suppressing ERK signaling in mice