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To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)

The decision to stop bisphosphonates in these cases needs to be carefully balanced against the risk of future fracture

High homocysteine is linked to cardiovascular disease, neurological disorders, and pregnancy complications

In line, intracellular GSH levels in B cells of HIV-1-infected individuals showed a tendency to be decreased compared to uninfected donors 30,125,126 , supporting the link between GSH and the regulation of B cell activation in human infections

Excessively low levels can cause a condition known as Laron Syndrome (dwarfism), which is usually diagnosed in childhood