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Furthermore, clinically attainable concentrations of PAC have been shown to decrease in vitro intracellular GSH in human pulmonary macrophages, type II pneumocytes, and lymphocytes (Estvez et al., 1994

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Similarly, another study revealed the succinylation of the classic tumor suppressor protein p53 at K120, with SIRT5 functioning as its desuccinylase

ABC proteins transport various molecules across extra-and intra-cellular membranes

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Prx3 is the Prx isoform exclusively located in mitochondria, suggesting that it plays a primary line of defense against H 2 O 2 produced by the mitochondrial respiratory chain