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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration

The specific radioactivity was 71.7 Ci/mmol, the radioactive purity was 99.6%, and the total amount was approximately 10 McUrie

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doi:10.1016/S0891-5849(98)00107-5

Key persisting challenges include the absence of universally accepted definitions for functional respirasome configurations, incomplete understanding of stoichiometric prerequisites enabling efficient electron flux, and insufficient mechanistic insights into inter-complex crosslinking modalities that stabilize these macromolecular assemblies