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For instance, activation of NRF2 promotes ROS clearance in drug-resistant liver cancer cell lines [31]

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Concerta : This CNS stimulant is also prescribed for ADHD in both adults and children, and the extended-release formulation can provide symptom relief for up to 12 hours.[4] Due to the CNS effects of this prescription stimulant, it is classified as a Schedule II controlled substance with a high potential for dependence and addiction

Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)

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