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For example, a well-known epigenetic change, DNA methylation, has been associated with inhibited expression of tumor suppressor genes

Pasquini S, Contri C, Merighi S, Gessi S, Borea PA, Varani K, et al

The reaction mechanism for roGFP2(S 2 ) as a model non-glutathione disulfide substrate resembles the first part of the GSH-dependent reduction of the sulfenic acid of human peroxiredoxin 6 that is catalyzed by glutathione transferase P1-1 (which shares several structural features with glutaredoxins) 7,80,81,82

Also, AD is known as a complex neurological disorder with increased amounts of both extracellular neuritic plaques and intracellular neurofibrillary tangles, which may also be related to lifestyle and genetic variables

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