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(2021a)

52 Inhibiting cystine import through system Xc induces ferroptosis, an iron-dependent, lipid peroxidation-mediated form of RCD, highlighting the importance of this antiporter in maintaining cellular GSH levels and redox balance 53 (Figure 2)

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10.3390/ijms251910535 [DOI] [PMC free article] [PubMed] [Google Scholar] Kaplan A, Zelicha H, Yaskolka Meir A, Rinott E, Tsaban G, Levakov G, Prager O, Salti M, Yovell Y, Ofer J, Huhn S, Beyer F, Witte V, Villringer A, Meiran N, Emesh BT, Kovacs P, von Bergen M, Ceglarek U, Blher M, Stumvoll M, Hu FB, Stampfer MJ, Friedman A, Shelef I, Avidan G, Shai I (2022) The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)