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Remarkably, carnosine, a naturally occurring dipeptide composed of -alanine and L-histidine, was identified as a consistently downregulated metabolite in both models ( Mechanistically, our in vitro data revealed that carnosine not only suppressed LPS-induced cytokine production in BMDMs but also inhibited their polarization toward the M1-like pro-inflammatory phenotype, which is known to exacerbate lung tissue damage (Yan et al., 2024

The main responsible mechanism is related to autoantibodies that bind and activate the thyrotropin receptor (TSHR)

10.1016/j.isci.2023.10773037694143 311 Li P, Zhang L, Zhang M, et al

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