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Physiologically, lens transparency is maintained by the highly ordered organization of crystallin proteins and robust antioxidant defense mechanisms, but oxidative stress-induced reactive oxygen species (ROS), glutathione depletion, protein oxidation, and glycation gradually destabilize the system, eventually leading to crystallin aggregation and light scattering that ultimately result in cataractogenesis 3,4

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[DOI] [PubMed] [Google Scholar] 63.Decramer M