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MLKL-deficient animals ( Mlkl / ) lack the specific necroptosis execution protein and are considered fully necroptosis deficient

Cell Rep Med 4(12):101340

Koronowski KB, Khoury N, Saul I, Loris ZB, Cohan CH, Stradecki-Cohan HM, Dave KR, Young JI, Perez-Pinzon MA

Moreover, excessive Wnt signaling activation is the main trigger of colon cancer initiation, and it is highly expressed in colon CSCs (Basu et al., 2013)