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This disorder of acylcarnitine metabolism promotes a continuous inflammatory response and thus plays a key role in the pathological process of N-ERD [45]

Acknowledgments The authors acknowledge the funding of the National Natural Science Foundation of China [No.82173989] and the support from the National Administration of Traditional Chinese Medicine [No.zyyzdxk-2023272]

doi: 10.1002/anie.202010618

While significant evidence connects TMAO to kidney disease, the exact mechanisms of how it causes kidney injury remain unclear

In addition to IL-10 and TGF- mentioned above, another immunomodulator that has been widely studied in tumor therapy is indoleamine-2, 3-dioxygenase 1 (IDO1) enzyme, which and its metabolites can inhibit T cell function, induce DCs apoptosis, and support Tregs phenotypic transformation