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10.1016/j.freeradbiomed.2012.03.017 272 NagourneyA

5 out of 5 starsReviewed on 2/6/2026 Dr

Hypoxia increases reactive oxygen species (ROS) generation through different mechanisms, including the electron transport chain disruption in the mitochondria, the hypoxanthine metabolism, and inflammatory cell activation 15

The Golgi apparatus hosts various components of the pro- and anti-apoptotic machinery, which indicates that it might be capable of sensing stress signals and thus contribute to the change in the cell fate direction [92]