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Elevated fatty acids (FAs) activate Toll-like receptors (TLRs) in macrophages, which act in synergy with MSU crystals to trigger NLRP3 inflammasome activation and pro-inflammatory cytokine release (e.g., IL-1), thereby initiating the inflammatory cascade

For example, if you hit the gym during the fasting window and your post-workout meal is your first meal of the feeding window, then it's generally wise to incorporate a generous amount of carbs in this meal

This is because, in some cases, the control group in the WMM review would be considered an intervention group in the BWMP review

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The injection is very easy to give yourself, and painless