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Li Y, Wang J, Yue J, Wang Y, Yang C, Cui Q (2018) High magnesium prevents matrix vesicle-mediated mineralization in human bone marrow-derived mesenchymal stem cells via mitochondrial pathway and autophagy

From this data, it can be clearly seen that pivalate prodrug 17 was the better substrate with a higher k cat /K M (458 M 1 s 1 ) compared to the citronellate prodrug 16 ( k cat /K M of 84 M 1 s 1 ) and benzoate 18 ( k cat /K M of 108.7 M 1 s 1 )

Interestingly, a recent study showed that oral supplementation of NR altered the intestinal microbial composition in rats and mice but not humans 63 , highlighting the need for further studies on this matter to assess the impact of NAD + metabolism modulation by the microbiome on health outcomes

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