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doi: 10.1001/jamaoncol.2018.4951 38 RomanoESimonRMinard-ColinVMartinVBockelSEspenelSet al

The approval was backed by results of a prespecified exploratory subgroup analysis by MMR status in the DUO-E Phase III trial where Imfinzi plus chemotherapy followed by Imfinzi monotherapy reduced the risk of disease progression or death by 58% versus chemo alone

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We would need large, placebo-controlled trials with proper imaging and functional outcome measures to confirm these effects in humans