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Description

Liver disease and arthritis tend to occur concomitantly

& Norris, C

The animal experimental designs are shown in Appendix Fig S3

BMC Gastroenterol 17:96 Kovacs-Nolan J, Rupa P, Matsui T, Tanaka M, Konishi T, Sauchi Y, Sato K, Ono S, Mine Y (2014) In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation

Further study showed that Tim-AIII promoted HSP90 expression and Tim-AIII induced cell death was blocked by the HSP90 inhibitor tanespimycin, indicating that HSP90 was the main target of Tim-AIII to further trigger intracellular events