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87,88,89 As the thymus shrinks, TCR diversity also decreases, impairing the ability of the immune system to respond effectively to novel pathogens 92

As a replacement strategy, lithium orotate (LiO), reported to bind A less avidly than lithium carbonate, raised parenchymal Li, reduced A and phospho-tau, and improved synaptic/myelin markers and behavior at physiological Li levels in AD mice, though these salt-specific advantages and translational implications remain preclinical [2123]

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