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508 The UPS regulates myeloid leukemia 1 (MCL-1), an anti-apoptotic protein upregulated in MS

In terms of biochemical characteristics, cells undergoing ferroptosis show an imbalance of oxidationreduction levels: a significant increase in intracellular reactive oxygen species (ROS) and a significant decrease in NADPH, and therefore lipid antioxidants can inhibit ferroptosis

N-Acetylcysteine a safe antidote for cysteine/glutathione deficiency

(Marashly & Bohlega 2017) The effectiveness of antioxidants in protecting against oxidative stress depends not only on their reactivity towards reactive oxygen species, but also on their role as recyclers