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Int J Mol Sci 19:1052

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Effects of glycowithanolides from Withania somnifera on an animal model of alzheimers disease and perturbed central cholinergic markers of cognition in rats

p47(phox) contributes to albuminuria and kidney fibrosis in mice

RSL3 binds to the nucleophilic active site of GPX4, and then reduces the expression level of GPX4 most effectively through chloroacetamide moiety (Jelinek et al., 2018), thus inactivating GPX4, producing lethal ROS accumulation and inducing ferroptosis