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Although most of the residues in those regions were identical or very similar between MRP1 and MRP2, synonymous mutations or difference in the choice of codons can result in serious protein misfolding 48

EGCG also influences the crosstalk between apoptotic and autophagic pathways through p53 and NF-B, allowing coordinated responses

This is especially damaging in neurodegenerative diseases as the chronic inflammatory state directly contributes to neuronal cell death and synaptic dysfunction

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Thats one of the reasons we won the 2016 Good Neighbor Pharmacy of the Year, a national award for independent pharmacies