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This metabolic reprogramming also supplies superoxide production, and induces ROS and hypochlorous acid, used in the neutrophil oxidative burst following phagocytosis of invading pathogens [211, 216,217,218]

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In studies of human recombinant MTHFR, the protein encoded by 1298C cannot be distinguished from 1298A in terms of activity, thermolability, FAD release, or the protective effect of 5-methyl-THF

Similarly, mice with LAMP-2 knocked out show impaired autophagy and autophagosomes aggregation in cardiomyocytes, resulting in cardiac defects 148

Leppert, P