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Of particular concern is the potential for increased bleeding risk, attributed mainly to ginkgolides platelet-activating factor (PAF) antagonism

6.3 Combining ferroptosis inhibition with standard therapies Integrating ferroptosis-targeted therapies with existing ARDS interventions, such as corticosteroids, immunomodulators, or mechanical ventilation, presents both opportunities and challenges

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Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal