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The table below lays out what a fair comparison can and cannot say, grading each available comparison by the strength of its underlying design

Furthermore, studies have indicated that vitamin B12 can mitigate renal toxicity induced by methotrexate in animal models [151], suggesting its potential role in ameliorating the adverse effects associated with certain MS therapies

Additionally, it is also a prominent target for cancer research due to its interplay with many chemotherapeutic treatments, radiation therapy and immune checkpoint inhibitors, which could lead to abscopal responses and improve patient outcome (105, 106)