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This selective activation underlines CHAC1s critical function in maintaining cellular homeostasis and its potential involvement in pathological conditions where ER stress is a significant factor (Mungrue et al., 2009)

121,122 Multiple lines of evidences have revealed that IDH1 is overexpressed in numerous cancers and is closely correlated with poor prognoses of patients with non-small cell lung carcinoma (NSCLC), 123 PDAC, 124 or one of several hematological malignancies

Cardiovascular benefits: Demonstrated in outcome trials, including reduced risk of major adverse cardiovascular events [6]

Similarly, pathway inhibition improves hepatocyte apoptosis in acute liver injury 50

Harnessing bacteria for tumor therapy: Current advances and challenges