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AMS occurs because your body isn't getting enough oxygen and you're breathing too much of the lower-oxygen air found at high elevations

The calculation we are finalizing for biosimilars for which negative or zero ASP data is reported for all NDCs, using a single calendar quarter of data, is most consistent with the Secretary's requirement under section 1847A(c)(5)(B) of the Act because the statute directs that Secretary to update quarterly a drug's ASP payment limit using manufacturer's ASP data from the most recent single calendar quarter for which such data are available, rather than several quarters