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Figure 1 Role of Magnesium in Oxidative Stress and Ocular Pathologies Oxidative stress (OS) is defined as an imbalance of oxidants to antioxidants, leading to lipid peroxidation and protein damage, further perpetuating an ongoing cycle of OS, causing aberrant ECM deposition, cytoskeletal changes within TM cell, and eventual apoptosis ( Specifically, magnesium deficiency disrupts the electron transport chain within the mitochondria by facilitating the uncoupling of oxidative phosphorylation leading to electron loss (56, 57)