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44,45 Estrogen appears to modulate pain perception in multiple ways, including through effects on nerve pathways and neurotransmitter function, influencing serotonin, dopamine, epinephrine, and endogenous opioid signaling

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They also can affect hormone regulation, immune function, skin health and even wound healing

The 90% confidence intervals for the loge-transformed AUC (0-t) and Cmax was 71.71% - 114.19% and 71.6% - 118.66% respectively

Regulation of shivering and non-shivering heat production during acclimation of rats