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Erika Suzuki Toledo (Escola Paulista de Medicina, Universidade Federal de So Paulo) for her critical revision of the manuscript and valuable comments

SLC7A11, which exchanges glutamine with cysteine, represents a promising therapeutic option

Glutathione-responsive nanosystems are engineered to remain stable in circulation but undergo structural changes or drug release specifically in high-GSH tumor cells, improving therapeutic precision and reducing off-target toxicity

doi: 10.1038/s41580-020-00324-8 27 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

TABLE 1 Phytochemicals for the treatment of interstitial cystitis