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Chronic alcohol exposure can lead to mitochondrial dysfunction, characterized by impaired ATP production and increased ROS generation (Hoyt et al

In the overall comparison between M0 and M12 (Patient-set: EHD), there were no significant changes in hippuric acid, p-cresyl sulfate, glyoxal, and 3-deoxyglucosone, while there were significant decreases in indoxyl sulfate and methylglyoxal at M12

Nicotinic acid (niacin) can stimulate histamine release, which, in turn, can stimulate gastric acid output

Prodrugs have evolved from being serendipitously discovered or used as a salvage effort to being intentionally designed

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