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10.1371/journal.ppat.0030044 PLoS Pathog

However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.

Lomonaco R, Ortiz-Lopez C, Orsak B, et al

USA 115 , E4661E4669 (2018)

46 Because middle-aged women, aged 4065 years, have the highest risk of developing fibromyalgia, hormone fluctuations that occur in the menopause transition have been proposed as a possible trigger