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Similar to previous studies in salivary glands (Avila et al , 2009), we found a 10 Gy dose induces DNA damage and cell cycle arrest, as well as reduces cell proliferation in the SLG in the first day following IR, as shown by a substantial increase in the proapoptotic gene Bax and the cell cycle inhibitor Cdkn1a (p21) (Fig EV4A) and a reduction in transcript levels of the cell proliferation marker Mki67 (Fig EV4A)

Long-lasting pain often means that several mechanisms are active at the same time: nerve irritation, medication tolerance, peripheral branch hypersensitivity, previous dental or surgical trauma, viral nerve injury, muscle spasm, or central sensitization

Mass spectrometrybased approachessuch as label-free quantification, TMT labeling, or targeted MRM/PRM workflowscan capture changes in phosphorylation states, transport proteins, metabolic enzymes, and signaling intermediates

Both Triamcinolone and Cortisone are corticosteroids and work through similar mechanisms

Standalone medical supply purchases typically remain prescription-free under federal rules