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Innate immune mechanisms, possibly involving misfolding and aggregation of serum amyloid A, might have a critical role in the pathobiology of sarcoidosis

After multivariable adjustment using Cox regression, ANA-positivity was associated with faster ALT normalization (HR 1.32, 95% CI 1.00-1.73, p=0.047) and SMA-positivity was associated with slower ALT normalization (HR 0.63, 95% CI 0.46-0.85, p=0.003) (Figure A)

Barley K, Dracheva S, Byne W (2009)

doi: 10.1538/expanim.23-0009 46

For individuals with cerebrovascular vascular insufficiency, a cerebrovasodilator, for example, Picamilon, could provide additional perfusion