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Li et al observed that endothelial cell pyroptosis is the dominant form of cell death in the initial phases of DMED development [89], and suppressing NOD-like receptor thermal protein domain associated protein 3 expression can significantly reduce pyroptotic activity in diabetic penile tissue of rats, enhancing the vascular endothelial function [91]

Moreover, Cyp2e1-null mice fed with ethanol developed centrilobular fat accumulation with upregulation of PPAR, suggesting an interplay between CYP2E1 and PPAR-mediated fatty acid homeostasis (Wan et al

ROS contributes to DNA methylation and damage, which results in mutations that turn healthy cells into cancerous cells [261]

doi: 10.1016/j.plaphy.2010.08.016 34 GuptaR.ChakrabartyS

Koyasu, S., Kobayashi, M., Goto, Y., Hiraoka, M