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285 Based on the above phenomena, researchers have developed therapeutic ideas to target Gln metabolism in tumor cells, increase the concentration of Gln in TME, and promote Gln metabolism in tumor-infiltrating cells

40 Despite NBDHEXs promising anticancer activity, consideration should be given to the relatively low GST-target selectivity and poor water-solubility

Drug metabolism proceeds in two phases Phase I is the addition of the polar group: the polarity of the drug is increased by oxidation or hydroxylation catalyzed by a family of microsomal cytochrome P-450 oxidases

M.Berdenis van BerlekomA.van der GeestA

It is unclear whether PDTC analog-driven proteasome inhibitors have similar protein substrate targets for tumor suppression (Yu et al., 2007