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More studies are needed to elucidate the mechanism behind the effect of GSH and large-scale trials are necessary to confirm the therapeutic role for GSH

Studies have shown that IGF-l and IGF1R mRNA expression in cultured young intervertebral disc cells is higher than that in mature cells, and the decrease of IGF-l dependent protein polysaccharide synthesis in rat NPCs is due to the downregulation of IGF-IR in late senescence (Osada et al., 1996

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HIF-1 and HIF-2 differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice