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The study evaluated pre-treatment vitamin D levels in samples taken from 1,191 early breast cancer patients prior to chemotherapy and, after accounting for other possible patient differences, looked at whether low vitamin D was associated with development of grade 3 CIPN

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Vitamin E, a lipid-soluble antioxidant, localizes to erythrocyte membranes, scavenges lipid peroxyl radicals, and maintains membrane fluidity and integrity, which mitigates ROS-induced membrane damage and Ca 2+ permeation

Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/akt-dependent activation of Nrf2

Intervention trials Community-based studies An early intervention trial of selenium supplementation was undertaken in China in 1985 among a general population of 130,471 individuals living in a high-risk area for viral hepatitis B infection and liver cancer